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Neuropsychiatric symptoms and functional decline in Alzheimerʼs disease and Lewy Body Dementia

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dc.contributor.authorBorda, Miguel Germán
dc.contributor.authorAarsland, Dag
dc.contributor.authorTovar-Rios, Diego A
dc.contributor.authorGiil, Lasse M.
dc.contributor.authorBallard, Clive
dc.contributor.authorGonzalez, Maria Camila
dc.contributor.authorBrønnick, Kolbjørnk
dc.contributor.authorAlves, Guido
dc.contributor.authorOppedal, Ketil
dc.contributor.authorSoennesyn, Hogne
dc.contributor.authorVik-Mo, Audun Osland
dc.contributor.corporatenamePontificia Universidad Javeriana. Facultad de Medicina. Instituto de Envejecimiento
dc.date.accessioned2021-04-16T04:14:50Z
dc.date.available2021-04-16T04:14:50Z
dc.date.created2020
dc.description.abstractenglishBackground/objectives: Functional status is one of the most important markers of well-being in older adults, but the drivers of functional decline in dementia are not well known. The aim of our work was to study the association of neuropsychiatric symptoms (NPSs) with functional decline over 5 years in newly diagnosed people with Alzheimer´s disease (AD) and Lewy body dementia (LBD). Design: Secondary analysis of the Dementia Study of Western Norway longitudinal cohort study. Setting: Multicenter study conducted in memory clinics in western Norway. Participants: We included a total of 196 patients newly diagnosed with AD (n = 111) and LBD (n = 85), followed up annually for 5 years. Main Outcomes and Measures: The outcome was the rapid disability rating scale (items 1-13). Linear mixed-effects models were used for analysis with the total score of the Norwegian Neuropsychiatric Inventory (NPI) as a predictor measured either at baseline or longitudinally, adjusted for potential confounders, including cognition. Effect modification was checked by introducing interactions with NPI score and stratifying by diagnosis. Results: The total NPI score longitudinal course was associated with functional decline in both AD and LBD. At baseline, the total NPI score predicted functional decline in AD. Conclusion: NPSs were associated with the rate of functional decline in people with AD and LBD, independent of cognitive impairment. These results highlight the relevance of early detection and intervention of NPSs, which may also reduce functional decline.spa
dc.description.indexingRevista Internacional - Indexadaspa
dc.description.quartilescopusQ1spa
dc.description.quartilewosQ1spa
dc.formatPDFspa
dc.format.mimetypeapplication/pdfspa
dc.identifierhttps://login.ezproxy.javeriana.edu.co/login?url=https://search.ebscohost.com/login.aspx?direct=true&db=mnh&AN=32738062&lang=es&site=eds-livespa
dc.identifier.doihttps://doi.org/10.1111/jgs.16709spa
dc.identifier.instnameinstname:Pontificia Universidad Javerianaspa
dc.identifier.issn0002-8614 / 1532-5415spa
dc.identifier.reponamereponame:Repositorio Institucional - Pontificia Universidad Javerianaspa
dc.identifier.repourlrepourl:https://repository.javeriana.edu.cospa
dc.identifier.urihttp://hdl.handle.net/10554/53582
dc.language.isoengspa
dc.relation.citationendpage2263spa
dc.relation.citationissue10spa
dc.relation.citationstartpage2257spa
dc.relation.citationvolume68spa
dc.relation.ispartofjournalJournal of the American Geriatrics Societyspa
dc.rights.coarhttp://purl.org/coar/access_right/c_abf2spa
dc.rights.licenceAtribución-NoComercial 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/*
dc.subject.keywordDementiaspa
dc.subject.keywordFunctional statusspa
dc.subject.keywordAlzheimerʼs diseasespa
dc.subject.keywordLewy body dementiaspa
dc.subject.keywordNeuropsychiatric symptomsspa
dc.titleNeuropsychiatric symptoms and functional decline in Alzheimerʼs disease and Lewy Body Dementiaspa
dc.type.coarhttp://purl.org/coar/resource_type/c_2df8fbb1spa
dc.type.hasversionhttp://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.localArtículo de revistaspa

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