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AURKA F31I Polymorphism and Breast Cancer Risk in BRCA1 and BRCA2 Mutation Carriers : A Consortium of Investigators of Modifiers of BRCA1/2 Study

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dc.contributor.authorCouch, Fergus J
dc.contributor.authorSinilnikova, Olga
dc.contributor.authorVierkant, Robert A.
dc.contributor.authorPankratz, V. Shane
dc.contributor.authorFredericksen, Zachary S.
dc.contributor.authorStoppa-Lyonnet, Dominique
dc.contributor.authorCoupier, Isabelle
dc.contributor.authorHughes, David
dc.contributor.authorHardouin, Agnès
dc.contributor.authorBerthet, Pascaline
dc.contributor.authorPeock, Susan
dc.contributor.authorCook, Margaret
dc.contributor.authorBaynes, Caroline
dc.contributor.authorHodgson, Shirley
dc.contributor.authorMorrison, Patrick J.
dc.contributor.authorPorteous, Mary E.
dc.contributor.authorJakubowska, Anna
dc.contributor.authorLubinski, Jan
dc.contributor.authorGronwald, Jacek
dc.contributor.authorSpurdle, Amanda B.
dc.contributor.authorSchmutzler, Rita
dc.contributor.authorVersmold, Beatrix
dc.contributor.authorEngel, Christoph
dc.contributor.authorMeindl, Alfons
dc.contributor.authorSutter, Christian
dc.contributor.authorHorst, Jurgen
dc.contributor.authorSchaefer, Dieter
dc.contributor.authorOffit, Kenneth
dc.contributor.authorKirchhoff, Tomas
dc.contributor.authorAndrulis, Irene L.
dc.contributor.authorIlyushik, Eduard
dc.contributor.authorGlendon, Gordon
dc.contributor.authorDevilee, Peter
dc.contributor.authorVreeswijk, Maaike P.G.
dc.contributor.authorVasen, Hans F.A.
dc.contributor.authorBorg, Ake
dc.contributor.authorBackenhorn, Katja
dc.contributor.authorStruewing, Jeffery P.
dc.contributor.authorGreene, Mark H.
dc.contributor.authorNeuhausen, Susan L.
dc.contributor.authorRebbeck, Timothy R.
dc.contributor.authorNathanson, Katherine
dc.contributor.authorDomchek, Susan
dc.contributor.authorWagner, Theresa
dc.contributor.authorGarber, Judy E.
dc.contributor.authorSzabo, Csilla
dc.contributor.authorZikan, Michal
dc.contributor.authorForetova, Lenka
dc.contributor.authorOlson, Janet E.
dc.contributor.authorSellers, Thomas A.
dc.contributor.authorLindor, Noralane
dc.contributor.authorNevanlinna, Heli
dc.contributor.authorTommiska, Johanna
dc.contributor.authorAittomaki, Kristiina
dc.contributor.authorHamann, Ute
dc.contributor.authorRashid, Muhammad
dc.contributor.authorTorres Lopez, Diana María
dc.contributor.authorSimard, Jacques
dc.contributor.authorDurocher, Francine
dc.contributor.authorGuenard, Frederic
dc.contributor.authorLynch, Henry T.
dc.contributor.authorIsaacs, Claudine
dc.contributor.authorWeitzel, Jeffrey
dc.contributor.authorOlopade, Olufunmilayo I.
dc.contributor.authorNarod, Steven
dc.contributor.authorDaly, Mary B.
dc.contributor.authorGodwin, Andrew K.
dc.contributor.authorTomlinson, Gail
dc.contributor.authorEaston, Douglas F.
dc.contributor.authorChenevix-Trench, Georgia
dc.contributor.authorAntoniouon, Antonis C.
dc.contributor.corporatenamePontificia Universidad Javeriana. Facultad de Medicina. Instituto de Genética Humana
dc.date.accessioned2019-10-28T20:55:11Z
dc.date.accessioned2020-04-15T13:33:19Z
dc.date.available2019-10-28T20:55:11Z
dc.date.available2020-04-15T13:33:19Z
dc.date.created2007
dc.description.abstractenglishThe AURKA oncogene is associated with abnormal chromosome segregation and aneuploidy and predisposition to cancer. Amplification of AURKA has been detected at higher frequency in tumors from BRCA1 and BRCA2 mutation carriers than in sporadic breast tumors, suggesting that overexpression of AURKA and inactivation of BRCA1 and BRCA2 cooperate during tumor development and progression. The F31I polymorphism in AURKA has been associated with breast cancer risk in the homozygous state in prior studies. We evaluated whether the AURKA F31I polymorphism modifies breast cancer risk in BRCA1 and BRCA2 mutation carriers from the Consortium of Investigators of Modifiers of BRCA1/2. Consortium of Investigators of Modifiers of BRCA1/2 was established to provide sufficient statistical power through increased numbers of mutation carriers to identify polymorphisms that act as modifiers of cancer risk and can refine breast cancer risk estimates in BRCA1 and BRCA2 mutation carriers. A total of 4,935 BRCA1 and 2,241 BRCA2 mutation carriers and 11 individuals carrying both BRCA1 and BRCA2 mutations was genotyped for F31I. Overall, homozygosity for the 31I allele was not significantly associated with breast cancer risk in BRCA1 and BRCA2 carriers combined [hazard ratio (HR), 0.91; 95% confidence interval (95% CI), 0.77-1.06]. Similarly, no significant association was seen in BRCA1 (HR, 0.90; 95% CI, 0.75-1.08) or BRCA2 carriers (HR, 0.93; 95% CI, 0.67-1.29) or when assessing the modifying effects of either bilateral prophylactic oophorectomy or menopausal status of BRCA1 and BRCA2 carriers. In summary, the F31I polymorphism in AURKA is not associated with a modified risk of breast cancer in BRCA1 and BRCA2 carriers.spa
dc.description.paginas1416-1421spa
dc.description.quartilescopusQ1spa
dc.format.soportePapel / Electrónicospa
dc.identifierhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2775799/spa
dc.identifier.doihttps://dx.doi.org/10.1158%2F1055-9965.EPI-07-0129spa
dc.identifier.issn1055-9965 / 1538-7755 (Electrónico)spa
dc.identifier.urihttp://hdl.handle.net/10554/45455
dc.languagespaspa
dc.rights.licenceAtribución-NoComercial 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/*
dc.sourceCancer Epidemiology, Biomarkers and Prevention; Vol. 16 Núm. 7 (2007)spa
dc.subject.keywordBRCA1spa
dc.subject.keywordBRCA2spa
dc.subject.keywordAURKAspa
dc.subject.keywordCIMBAspa
dc.subject.keywordBreast cancer riskspa
dc.titleAURKA F31I Polymorphism and Breast Cancer Risk in BRCA1 and BRCA2 Mutation Carriers : A Consortium of Investigators of Modifiers of BRCA1/2 Studyspa
dc.typeinfo:eu-repo/semantics/article
dc.type.localArtículo de revistaspa

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