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Pulmonary adenofibromas : a clinicopathologic correlation of 13 cases

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dc.contributor.authorLindholm, Kaleigh E
dc.contributor.authorSansano Valero, Irene
dc.contributor.authorRodríguez, Jorge L
dc.contributor.authorRamon Y Cajal, Santiago
dc.contributor.authorMoran, Cesar A
dc.contributor.corporatenamePontificia Universidad Javeriana. Facultad de Medicina. Departamento de Patología
dc.date.accessioned2021-03-20T03:05:39Z
dc.date.available2021-03-20T03:05:39Z
dc.date.created2020-07
dc.description.abstractenglishThirteen cases of primary pulmonary adenofibromas are presented. The patients are 8 women and 5 men between the ages of 41 and 73 years (average: 57 y). The patients presented with nonspecific symptomatology or their tumor was identified during routine chest films. A wedge resection was performed in all cases with lymph node sampling. Grossly, the tumors varied in size from 1 to 2.5 cm in greatest dimension. The entire tumor was histologically evaluated in all cases. All the tumors shared similar histologic features namely leaf-like/phyllodes-like growth patterns with varying areas of sclerosis, focal inflammation, and entrapped epithelium. A wide panel of immunohistochemical studies was performed including epithelial, neural, muscle, and vascular markers, all of which showed negative staining. The tumors were positive only for vimentin in the stroma and keratin in the entrapped epithelium. Further evaluation in 6 cases using in situ hybridization for the solitary fibrous tumor was performed and was negative. Clinical follow-up in all the patients showed no evidence of recurrence or metastatic disease, during a period of 12 to 36 months. The current cases highlight the unusual occurrence of pulmonary adenofibromas and the importance of separating these tumors from other tumors that may have the potential to recur or metastasize. The use of proper immunohistochemical stains/molecular analysis aids in the proper classification of these tumors.spa
dc.description.indexingN/Aspa
dc.description.quartilescopusQ1spa
dc.description.quartilewosQ1spa
dc.formatPDFspa
dc.format.mimetypeapplication/pdfspa
dc.identifierhttps://login.ezproxy.javeriana.edu.co/login?url=https://search.ebscohost.com/login.aspx?direct=true&db=edselc&AN=edselc.2-52.0-85086346526&lang=es&site=eds-livespa
dc.identifier.doihttps://doi.org/10.1097/PAS.0000000000001456spa
dc.identifier.instnameinstname:Pontificia Universidad Javerianaspa
dc.identifier.issn0147-5185 / 1532-0979 (Electrónico)spa
dc.identifier.reponamereponame:Repositorio Institucional - Pontificia Universidad Javerianaspa
dc.identifier.repourlrepourl:https://repository.javeriana.edu.cospa
dc.identifier.urihttp://hdl.handle.net/10554/53307
dc.language.isoengspa
dc.relation.citationendpage921spa
dc.relation.citationissue7spa
dc.relation.citationstartpage917spa
dc.relation.citationvolume44spa
dc.relation.ispartofjournalThe American Journal of Surgical Pathologyspa
dc.rights.coarhttp://purl.org/coar/access_right/c_abf2spa
dc.rights.licenceAtribución-NoComercial 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/*
dc.subject.keywordThoraxspa
dc.subject.keywordLungspa
dc.subject.keywordAdenofibromaspa
dc.subject.keywordImmunohistochemistryspa
dc.titlePulmonary adenofibromas : a clinicopathologic correlation of 13 casesspa
dc.type.coarhttp://purl.org/coar/resource_type/c_2df8fbb1spa
dc.type.hasversionhttp://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.localArtículo de revistaspa

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