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Epithelial-mesenchymal transition, proliferation, and angiogenesis in locally advanced cervical cancer treated with chemoradiotherapy

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dc.contributor.authorRojas-Puentes, Leonardo
dc.contributor.authorCardona, Andrés F.
dc.contributor.authorCarranza, Hernán
dc.contributor.authorVargas, Carlos
dc.contributor.authorJaramillo, Luis F.
dc.contributor.authorZea, Delma
dc.contributor.authorCetina, Lucely
dc.contributor.authorWills, Beatriz
dc.contributor.authorRuiz-Garcia, Erika
dc.contributor.authorArrieta, Oscar
dc.contributor.corporatenamePontificia Universidad Javeriana. Facultad de Medicina. Departamento de Medicina Interna. Grupo de Investigación de Enfermedades Crónicas del Adulto
dc.date.accessioned2020-06-03T02:28:23Z
dc.date.available2020-06-03T02:28:23Z
dc.date.created2016-05-27
dc.description.abstractenglishWe evaluated the association between epithelial–mesenchymal transition (EMT )‐derived markers and expression of proteins associated with cell proliferation and tumor growth, as well as their prognostic roles, in 61 patients (mean age 52 ± 10 years) with locally advanced cervical cancer, all of whom were treated with chemoradiation and intracavitary brachytherapy. We used immunohistochemical analysis to assess the expression of proteins targeted in our investigation. Various statistical analyses were then conducted to assess protein marker associations with survival outcomes. Forty‐six percent of the patients were positive for human papilloma virus. Median progression‐free survival (PFS ) was 6.6 months (95% confidence interval [CI ]: 4.0–9.1, whereas overall survival (OS ) was 30.0 months (95% CI : 11–48). Multivariate analysis demonstrated that vascular endothelial growth factor (VEGF ) (P = 0.002), epidermal growth factor receptor (EGFR ) (P = 0.001), and TWIST 2 (P = 0.001) expression levels, as well as a tumor size <6 cm (P = 0.02), influenced OS . Changes in TWIST 2 levels and loss of E‐cadherin expression were correlated with VEGF and EGFR levels; furthermore, patients with high TWIST 2 expression had shorter OS (P = 0.0001), as those with loss of E‐cadherin (P = 0.02). OS was even shorter when positive EGFR or VEGF expression was related with EMT markers (positive EGFR + negative E‐cadherin: median 14 months, 95% CI : 3–24; negative EGFR + positive E‐cadherin: median 31 months, 95% CI : 14–NA ; P = 0.02.). The presence of EMT markers was associated with proliferative and pro‐angiogenic protein expression and influenced the prognosis of locally advanced cervical cancer.spa
dc.description.paginas1989-1999spa
dc.description.quartilescopusQ1spa
dc.description.tipoarticuloArtículo originalspa
dc.formatPDFspa
dc.format.mimetypeapplication/pdfspa
dc.format.soportePapel / Electrónicospa
dc.identifierhttps://onlinelibrary.wiley.com/doi/10.1002/cam4.751spa
dc.identifier.doihttps://doi.org/10.1002/cam4.751spa
dc.identifier.issn1475-8075 / 2045-7634 (Electronico)spa
dc.identifier.urihttp://hdl.handle.net/10554/49589
dc.languagespaspa
dc.rights.licenceAtribución-NoComercial 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/*
dc.sourceCancer Medicine; Vol. 5 Núm. 8 (2016)spa
dc.subject.keywordAngiogenesis epidermal growth factor receptorspa
dc.subject.keywordCervical neoplasmsspa
dc.subject.keywordEpithelial–mesenchymal transitionspa
dc.subject.keywordGene expressionspa
dc.titleEpithelial-mesenchymal transition, proliferation, and angiogenesis in locally advanced cervical cancer treated with chemoradiotherapyspa
dc.title.englishEpithelial-mesenchymal transition, proliferation, and angiogenesis in locally advanced cervical cancer treated with chemoradiotherapyspa
dc.typeinfo:eu-repo/semantics/article
dc.type.hasversionhttp://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.localArtículo de revistaspa

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