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Role of VEGF in the differential growth between the fetal and placental ends of the umbilical cord

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dc.contributor.authorOlaya C, Mercedes
dc.contributor.authorMichael, F
dc.contributor.authorG, Fabian
dc.contributor.authorSilva, J Luis
dc.contributor.authorGarzon, A L
dc.contributor.authorBernal, J E
dc.contributor.corporatenamePontificia Universidad Javeriana. Facultad de Medicina. Departamento de Patología
dc.contributor.corporatenameResearch Seedbed in Perinatal Medicine Pontificia Universidad Javeriana
dc.date.accessioned2021-03-23T15:40:03Z
dc.date.available2021-03-23T15:40:03Z
dc.date.created2019
dc.description.abstractenglishIntroduction: The umbilical cord (UC) is a vital structure; its alterations affect the newborn and neurological impact can be permanent. Paradoxically, factors that determine it remain unknown. We explore the differential VEGF protein expression in the UC's proximal and distal portions in relation to the hypothesis that the UC has differential growth and that VEGF plays a role in it. Methods: An observational analytical study was performed. One UC segment was taken proximal to fetus and another distal; both were randomly processed; VEGF immunohistochemical analysis was performed; two blinded pathologists read results. Results: Forty-eight newborns were included. Protein expression between the two edges of the umbilical cord, in any kind of cells, was interpreted. Endothelium, amnion, and stromal cells expressed VEGF; the first two were not different between opposite ends. Stromal cells had differential expression: higher in the proximal to the fetus portion. Conclusion: Knowledge of molecular factors is necessary. UC cells widely expressed VEGF, possibly contributing to UC growth. Even though stromal cell expression was different, the interaction with activity close to the fetus must be explored.spa
dc.description.indexingN/Aspa
dc.description.orcidhttps://orcid.org/0000-0002-7147-425Xspa
dc.description.quartilescopusQ3spa
dc.formatPDFspa
dc.format.mimetypeapplication/pdfspa
dc.identifierhttps://login.ezproxy.javeriana.edu.co/login?url=https://search.ebscohost.com/login.aspx?direct=true&db=edselc&AN=edselc.2-52.0-85064122819&lang=es&site=eds-livespa
dc.identifier.doihttps://doi.org/10.3233/NPM-1795spa
dc.identifier.instnameinstname:Pontificia Universidad Javerianaspa
dc.identifier.issn1934-5798spa
dc.identifier.reponamereponame:Repositorio Institucional - Pontificia Universidad Javerianaspa
dc.identifier.repourlrepourl:https://repository.javeriana.edu.cospa
dc.identifier.urihttp://hdl.handle.net/10554/53316
dc.language.isoengspa
dc.relation.citationendpage56spa
dc.relation.citationissue1spa
dc.relation.citationstartpage47spa
dc.relation.citationvolume12spa
dc.relation.ispartofjournalJournal of Neonatal-Perinatal Medicinespa
dc.rights.coarhttp://purl.org/coar/access_right/c_abf2spa
dc.rights.licenceAtribución-NoComercial 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/*
dc.subject.keywordUmbilical cordspa
dc.subject.keywordVEGFspa
dc.subject.keywordStillbirthspa
dc.subject.keywordUmbilical cord lengthspa
dc.titleRole of VEGF in the differential growth between the fetal and placental ends of the umbilical cordspa
dc.type.coarhttp://purl.org/coar/resource_type/c_6501spa
dc.type.hasversionhttp://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.localArtículo de revistaspa

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