Logotipo del repositorio
 

Soluble concentrations of the terminal complement complex C5b-9 correlate with end-organ injury in preeclampsia

Vista sencilla de ítem
dc.contributor.authorValencia, Catalina M.
dc.contributor.authorHersh, Alyssa R.
dc.contributor.authorBurwick, Richard M.
dc.contributor.authorVelásquez, Jesús A.
dc.contributor.authorGutiérrez-Marín, Jorge
dc.contributor.authorEdna, Francisco
dc.contributor.authorSilva Herrera, Jaime Luis
dc.contributor.authorTrujillo-Otálvaro, Juliana
dc.contributor.authorVargas-Rodríguez, Johanna
dc.contributor.authorBernal, Yamile
dc.contributor.authorQuintero, Alvaro
dc.contributor.authorRincón, Mónica
dc.contributor.authorTolosa, Jorge E.
dc.contributor.corporatenamePontificia Universidad Javeriana. Facultad de Medicina. Departamento de Ginecología y Obstetriciaspa
dc.contributor.javerianateacherSilva Herrera, Jaime Luis
dc.coverage.spatialColombiaspa
dc.coverage.temporal2015-2016
dc.date.accessioned2023-03-14T13:12:48Z
dc.date.available2023-03-14T13:12:48Z
dc.date.created2022-07-06
dc.description.abstractenglishObjective: We sought to determine if soluble levels of C5b-9, the terminal complement complex, correlate with end-organ injury in preeclampsia. Study Design: Project COPA (Complement and Preeclampsia in the Americas), a multi-center observational study in Colombia from 2015 to 2016, enrolled hypertensive pregnant women into four groups: chronic hypertension, gestational hypertension, preeclampsia, and preeclampsia with severe features. Trained coordinators collected clinical data, blood and urine. End-organ injury was defined by serum creatinine ≥ 1.0 mg/dl, aspartate transaminase ≥ 70U/L, platelet count < 150,000/µl, or lactate dehydrogenase ≥ 500 U/L. Data were analyzed by χ2 or Fisher’s exact test with significance at P < 0.05. Main Outcome Measure: C5b-9 concentrations in plasma and urine, using enzyme linked immunosorbent assays. Results: In total, 298 hypertensive participants were enrolled. Plasma and urine C5b-9 levels were measured in all participants and stratified by quartile (Q1-4), from lowest to highest C5b-9 concentration. Participants with low plasma C5b-9 levels (Q1) were more likely to have end-organ injury compared to those with higher levels (Q2-Q4) [platelet count < 150,000/μl (20.8% vs. 8.4%, P = 0.01); elevated serum creatinine ≥ 1.0 mg/dl (14.9% vs. 4.5%, P = 0.009)]. In contrast, participants with high urinary C5b-9 levels (Q4) were more likely to have end-organ injury compared to those with lower levels (Q1-Q3) [platelet count < 150,000/μl (19.7% vs. 7.4%, P = 0.003); elevated serum creatinine ≥ 1.0 mg/dl (12.3% vs. 4.4%, P = 0.025)]. Conclusion: We identified a pattern of increased urine and low plasma C5b-9 levels in patients with preeclampsia and end-organ injury. Soluble C5b-9 levels may be used to identify complement-mediated end-organ injury in preeclampsia.spa
dc.description.comunidadPacientes embarazadas hipertensasspa
dc.description.esciNospa
dc.description.indexingRevista Internacional - Indexadaspa
dc.description.orcidhttps://orcid.org/0000-0001-6822-0374spa
dc.description.publindexA1spa
dc.description.quartilescopusQ1spa
dc.description.quartilewosQ3spa
dc.formatPDFspa
dc.format.mimetypeapplication/pdfspa
dc.identifierhttps://search-ebscohost-com.ezproxy.javeriana.edu.co/login.aspx?direct=true&AuthType=sso&db=edselp&AN=S221077892200068X&lang=es&site=eds-live&scope=site&authtype=sso&custid=s6670599spa
dc.identifier.doihttps://doi.org/10.1016/j.preghy.2022.07.001spa
dc.identifier.instnameinstname:Pontificia Universidad Javerianaspa
dc.identifier.issn2210-7789 / 2210-7797 (Electrónico)spa
dc.identifier.reponamereponame:Repositorio Institucional - Pontificia Universidad Javerianaspa
dc.identifier.repourlrepourl:https://repository.javeriana.edu.cospa
dc.identifier.urihttp://hdl.handle.net/10554/63743
dc.language.isoengspa
dc.relation.citationendpage97spa
dc.relation.citationstartpage92spa
dc.relation.citationvolume29spa
dc.relation.ispartofjournalPregnancy Hypertensionspa
dc.rights.coarhttp://purl.org/coar/access_right/c_abf2spa
dc.rights.licenceAtribución-NoComercial 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/*
dc.subject.keywordComplement membrane attack complexspa
dc.subject.keywordComplement system proteinsspa
dc.subject.keywordHypertensionspa
dc.subject.keywordPreeclampsiaspa
dc.subject.keywordPregnancyspa
dc.titleSoluble concentrations of the terminal complement complex C5b-9 correlate with end-organ injury in preeclampsiaspa
dc.type.coarhttp://purl.org/coar/resource_type/c_6501spa
dc.type.hasversionhttp://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.localArtículo de revistaspa

Archivos

Bloque original
Mostrando 1 - 1 de 1
Miniatura
Nombre:
Soluble concentrations of the terminal complement complex C5b-9 correlate with end-organ injury in preeclampsia.pdf
Tamaño:
609.23 KB
Formato:
Adobe Portable Document Format
Descripción:
Artículo
Descargar
Bloque de licencias
Mostrando 1 - 1 de 1
No hay miniatura disponible
Nombre:
license.txt
Tamaño:
2.54 KB
Formato:
Item-specific license agreed upon to submission
Descripción:
Descargar

Colecciones

Artículos