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D-dimer trends elaborate the heterogeneity of risk in hospitalized patients with COVID-19: A multi-national case series from different waves

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dc.contributor.authorRonderos Botero, Diana Maria
dc.contributor.authorSalem Omar, Alaa Mabrouk
dc.contributor.authorPengo, Martino F.
dc.contributor.authorWaqas Haider, Syed
dc.contributor.authorLatif, Hira
dc.contributor.authorParati, Gianfranco
dc.contributor.authorPengo, Vittorio
dc.contributor.authorCanas, Alejandra
dc.contributor.authorDiaz, Melissa
dc.contributor.authorVillaquirán-Torres, Claudio
dc.contributor.authorContreras, Johanna
dc.contributor.authorChilimuri, Sridhar
dc.contributor.corporatenamePontificia Universidad Javeriana. Facultad de Medicina. Departamento de Medicina Interna. Neumologíaspa
dc.contributor.javerianateacherCanas, Alejandra
dc.contributor.javerianateacherVillaquirán-Torres, Claudio
dc.coverage.spatialColombiaspa
dc.coverage.spatialEstados Unidosspa
dc.coverage.spatialItaliaspa
dc.coverage.temporal2020-2021spa
dc.date.accessioned2023-08-31T14:27:44Z
dc.date.available2023-08-31T14:27:44Z
dc.date.created2023-03-17
dc.description.abstractenglishIntroduction: Variable D-dimer trends during hospitalization reportedly result in distinct in-hospital mortality. In this multinational case series from the first and second waves, we show the universality of such D-dimer trends. Methods: We reviewed 405 patients with COVID-19 during the first wave admitted to three institutions in the United States, Italy, and Colombia, and 111 patients admitted to the U.S. site during the second wave and 55 patients during the third wave. D-dimer was serially followed during hospitalization. Results: During the first wave, 66 (15%) patients had a persistently-low pattern, 33 (8%) had early-peaking, 70 (16%) had mid-peaking, 94 (22%) had fluctuating, 30 (7%) had late-peaking, and 112 (26%) had a persistently-high pattern. During the second and third waves, similar patterns were observed. D-dimer patterns were significantly different in terms of in-hospital mortality similarly in all waves. Patterns were then classified into low-risk patterns (persistently-low and early-peaking), where no deaths were observed in both waves, high-risk patterns (mid-peaking and fluctuating), and malignant patterns (late-peaking and persistently-high). Overall, D-dimer trends were associated with an increased risk for in-hospital mortality in the first wave (overall: HR: 1.73) and stayed the same during the second (HR: 1.67, p < 0.001) and the third (HR: 4.4, p = 0.001) waves. Conclusion: D-dimer behavior during COVID-19 hospitalization yielded universal categories with distinct mortality risks that persisted throughout all studied waves of infection. Monitoring D-dimer behavior may be useful in the management of these patients.spa
dc.description.comunidadPacientes con COVID-19spa
dc.description.esciNospa
dc.description.indexingRevista Internacional - Indexadaspa
dc.description.orcidhttps://orcid.org/0000-0003-3975-2835spa
dc.description.orcidhttps://orcid.org/0000-0003-2297-1855spa
dc.description.orcidhttps://orcid.org/0000-0002-3743-6268spa
dc.description.publindexA1spa
dc.description.quartilescopusQ1spa
dc.description.quartilewosQ2spa
dc.formatPDFspa
dc.format.mimetypeapplication/pdfspa
dc.identifierhttps://www.frontiersin.org/articles/10.3389/fmed.2023.1103842/fullspa
dc.identifier.doihttps://doi.org/10.3389/fmed.2023.1103842spa
dc.identifier.instnameinstname:Pontificia Universidad Javerianaspa
dc.identifier.issn2296-858Xspa
dc.identifier.reponamereponame:Repositorio Institucional - Pontificia Universidad Javerianaspa
dc.identifier.repourlrepourl:https://repository.javeriana.edu.cospa
dc.identifier.urihttp://hdl.handle.net/10554/65359
dc.language.isoengspa
dc.relation.citationendpage11spa
dc.relation.citationstartpage1spa
dc.relation.citationvolume10spa
dc.relation.ispartofjournalFrontiers in Medicinespa
dc.rights.coarhttp://purl.org/coar/access_right/c_abf2spa
dc.rights.licenceAtribución-NoComercial 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/*
dc.subject.keywordCOVID-19spa
dc.subject.keywordD-dimerspa
dc.subject.keywordVariabilityspa
dc.subject.keywordIn-hospital mortalityspa
dc.subject.keywordHeterogeneityspa
dc.titleD-dimer trends elaborate the heterogeneity of risk in hospitalized patients with COVID-19: A multi-national case series from different wavesspa
dc.type.coarhttp://purl.org/coar/resource_type/c_2df8fbb1spa
dc.type.hasversionhttp://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.localArtículo de revistaspa

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