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Brainstem neuromelanin and iron MRI reveals a precise signature for idiopathic and LRRK2 Parkinson’s disease

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dc.contributor.authorMartínez, Martín
dc.contributor.authorAriz, Mikel
dc.contributor.authorAlvarez, Ignacio
dc.contributor.authorCastellanos, Gabriel
dc.contributor.authorAguilar, Miquel
dc.contributor.authorHernández-Vara, Jorge
dc.contributor.authorCaballol, Núria
dc.contributor.authorGarrido, Alicia
dc.contributor.authorBayés, Àngels
dc.contributor.authorVilas, Dolores
dc.contributor.authorMarti, Maria Jose
dc.contributor.authorPastor, Pau
dc.contributor.authorOrtiz de Solórzano, Carlos
dc.contributor.authorPastor, Maria A.
dc.contributor.corporatenamePontificia Universidad Javeriana. Facultad de Medicina. Departamento de Ciencias Fisiológicasspa
dc.contributor.corporatenameThe Catalonian Neuroimaging Parkinson’s disease Consortiumspa
dc.contributor.javerianateacherCastellanos, Gabriel
dc.coverage.temporal2018-2020spa
dc.date.accessioned2023-08-31T14:56:11Z
dc.date.available2023-08-31T14:56:11Z
dc.date.created2023-04-15
dc.description.abstractenglishNeuromelanin (NM) loss in substantia nigra pars compacta (SNc) and locus coeruleus (LC) reflects neuronal death in Parkinson’s disease (PD). Since genetically-determined PD shows varied clinical expressivity, we wanted to accurately quantify and locate brainstem NM and iron, to discover whether specific MRI patterns are linked to Leucine-rich repeat kinase 2 G2019S PD (LRRK2-PD) or idiopathic Parkinson’s disease (iPD). A 3D automated MRI atlas-based segmentation pipeline (3D-ABSP) for NM/iron-sensitive MRI images topographically characterized the SNc, LC, and red nucleus (RN) neuronal loss and calculated NM/iron contrast ratio (CR) and normalized volume (nVol). Left-side NM nVol was larger in all groups. PD had lower NM CR and nVol in ventral-caudal SNc, whereas iron increased in lateral, medial-rostral, and caudal SNc. The SNc NM CR reduction was associated with psychiatric symptoms. LC CR and nVol discriminated better among subgroups: LRRK2-PD had similar LC NM CR and nVol as that of controls, and larger LC NM nVol and RN iron CR than iPD. PD showed higher iron SNc nVol than controls, especially among LRRK2-PD. ROC analyses showed an AUC > 0.92 for most pairwise subgroup comparisons, with SNc NM being the best discriminator between HC and PD. NM measures maintained their discriminator power considering the subgroup of PD patients with less than 5 years of disease duration. The SNc iron CR and nVol increase was associated with longer disease duration in PD patients. The 3D-ABSP sensitively identified NM and iron MRI patterns strongly correlated with phenotypic PD features.spa
dc.description.comunidadPacientes con Enfermedad de Parkinsonspa
dc.description.esciNospa
dc.description.indexingRevista Internacional - Indexadaspa
dc.description.orcidhttps://orcid.org/0000-0001-8121-1552spa
dc.description.publindexA1spa
dc.description.quartilescopusQ1spa
dc.description.quartilewosQ1spa
dc.formatPDFspa
dc.format.mimetypeapplication/pdfspa
dc.identifierhttps://www.nature.com/articles/s41531-023-00503-2#citeasspa
dc.identifier.doihttps://doi.org/10.1038/s41531-023-00503-2spa
dc.identifier.instnameinstname:Pontificia Universidad Javerianaspa
dc.identifier.issn2373-8057spa
dc.identifier.reponamereponame:Repositorio Institucional - Pontificia Universidad Javerianaspa
dc.identifier.repourlrepourl:https://repository.javeriana.edu.cospa
dc.identifier.urihttp://hdl.handle.net/10554/65363
dc.language.isoengspa
dc.relation.citationendpage11spa
dc.relation.citationstartpage1spa
dc.relation.citationvolume9spa
dc.relation.ispartofjournalnpj Parkinson's Diseasespa
dc.rights.coarhttp://purl.org/coar/access_right/c_abf2spa
dc.rights.licenceAtribución-NoComercial 4.0 Internacional*
dc.source.urihttp://creativecommons.org/licenses/by-nc/4.0/*
dc.titleBrainstem neuromelanin and iron MRI reveals a precise signature for idiopathic and LRRK2 Parkinson’s diseasespa
dc.type.coarhttp://purl.org/coar/resource_type/c_6501spa
dc.type.hasversionhttp://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.localArtículo de revistaspa

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