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Spiral arteries in second trimester of pregnancy : when is it possible to define expected physiological remodeling as abnormal?

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dc.contributor.authorOlaya C, Mercedes
dc.contributor.authorGarrido, Marta
dc.contributor.authorFranco, Jorge Andrés
dc.contributor.authorRodríguez, Jorge Luis
dc.contributor.authorJimena Vargas, Magda
dc.contributor.authorAula Olivar, Ana
dc.contributor.authorQuintero, Laura
dc.contributor.authorRamón y Cajal, Santiago
dc.contributor.corporatenamePontificia Universidad Javeriana. Facultad de Medicina. Departamento de Patología
dc.date.accessioned2021-03-20T02:02:03Z
dc.date.available2021-03-20T02:02:03Z
dc.date.created2021-04
dc.description.abstractenglishAfter undergoing remodeling, uterine spiral arteries turn into wide, flexible tubes, with low resistance. If remodeling does not occur, spontaneous abortions, intrauterine growth restriction, and pregnancy-related hypertensive disorders can ensue. Arterial transformation begins at a very early gestational stage; however, second quarter pregnancy histopathological samples have yet to pinpoint the exact moment when abnormal remodeling transpires. We examined 100 samples, taken from consecutive abortions at 12–23 gestational weeks. Following Pijnenborg and Smith guidelines, blinded pathologists analyzed clinical data on remod eling stages. Lab results showed that arterial remodeling is not synchronic in all vessels; a single sample can include various remodeling stages; neither is remodeling homogenous in a single vessel: change may be occurring in one part of the vessel, but not in another. To our knowledge, no one has published this finding. In the examined age group, Smith stage IV predominates; around week 14, substantial muscle and endothelium loss takes place. After week 17, endovascular or fibrin trophoblast does not usually occur. Although scant consensus exists on what defines preeclampsia etiology, it is clear that it involves abnormal remodeling in decidua vessels. Improved understanding requires further knowledge on both the physiological and pathological aspects of the remodeling process. We observed that muscle and endothelial tissues disappear from weeks 14–17, after which time reendothelization predominates. We list the expected proportion of spiral artery changes for each gestational age which, to date, has not been available.spa
dc.description.indexingN/Aspa
dc.description.orcidhttps://orcid.org/0000-0002-7147-425Xspa
dc.description.quartilescopusQ2spa
dc.description.quartilewosQ2spa
dc.formatPDFspa
dc.format.mimetypeapplication/pdfspa
dc.identifierhttps://link-springer-com.ezproxy.javeriana.edu.co/article/10.1007/s43032-020-00403-3#Ack1spa
dc.identifier.doihttps://doi.org/10.1007/s43032-020-00403-3spa
dc.identifier.instnameinstname:Pontificia Universidad Javerianaspa
dc.identifier.issn1933-7191 / 1933-7205 (Electrónico)spa
dc.identifier.reponamereponame:Repositorio Institucional - Pontificia Universidad Javerianaspa
dc.identifier.repourlrepourl:https://repository.javeriana.edu.cospa
dc.identifier.urihttp://hdl.handle.net/10554/53304
dc.language.isoengspa
dc.relation.citationendpage1193spa
dc.relation.citationstartpage1185spa
dc.relation.citationvolume28spa
dc.relation.ispartofjournalReproductive Sciencesspa
dc.rights.coarhttp://purl.org/coar/access_right/c_abf2spa
dc.rights.licenceAtribución-NoComercial 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/*
dc.subject.keywordSpiral arteriesspa
dc.subject.keywordVascular remodelingspa
dc.subject.keywordEndovascular trophoblastspa
dc.subject.keywordTrophoblast invasionspa
dc.subject.keywordPreeclampsiaspa
dc.titleSpiral arteries in second trimester of pregnancy : when is it possible to define expected physiological remodeling as abnormal?spa
dc.type.coarhttp://purl.org/coar/resource_type/c_6501spa
dc.type.hasversionhttp://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.localArtículo de revistaspa

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