A TGF-B mediated regulatory mechanism modulates the T cell immune response to rotavirus in adults but not in children
| dc.contributor.author | Mesa Villanueva, Martha Cecilia | |
| dc.contributor.author | Gutiérrez Zapata, Lina María | |
| dc.contributor.author | Duarte Rey, Carolina | |
| dc.contributor.author | Ángel Uribe, Juanita | |
| dc.contributor.author | Franco Cortés, Manuel Antonio | |
| dc.contributor.corporatename | Pontificia Universidad Javeriana. Facultad de Medicina. Instituto de Genética Humana | |
| dc.date.accessioned | 2019-11-28T13:48:04Z | |
| dc.date.accessioned | 2020-04-15T13:31:13Z | |
| dc.date.available | 2019-11-28T13:48:04Z | |
| dc.date.available | 2020-04-15T13:31:13Z | |
| dc.date.created | 2010-01-22 | |
| dc.description.abstractenglish | Children with acute RV-gastroenteritis (GE) had low or undetectable levels of circulating IFN-γ+, IL-13+, IL-2+, IL-10+ or IL-17+ RV-T cells. IFN-γ+ T cells and low frequencies of IL-10+ and IL-2+ CD4+ T cells were found in adults with RV-GE during acute and convalescence phases, respectively. Circulating single IFN-γ+ > double IFN-γ+/IL-2+ > single IL-2+RV-CD4+T cells were observed in healthy adults. In this group, frequencies of IFN-γ+ RV-T cells increased after removing CD25+cells, blocking TGF-β with its natural inhibitor, LAP, or inhibiting TGF-βRI signalling pathway with ALK5i. The frequencies of IFN-γ+ RV-T cells were also incremented in PBMC depleted of CD25+cells and treated with ALK5i, suggesting that TGFβ inhibition may be independent of Treg cells. The ALK5i effect was observed in adults but not in children with RV-GE, who had normal numbers of TGF-β+ Treg cells. Thus, a TGF-β-mediated regulatory mechanism that modulates RV-T cells in adults is not evident in children. | spa |
| dc.description.paginas | 77-86 | spa |
| dc.description.quartilescopus | Q2 | spa |
| dc.description.quartilewos | Q3 | spa |
| dc.format.soporte | Papel / Electrónico | spa |
| dc.identifier | https://www-sciencedirect-com.ezproxy.javeriana.edu.co/science/article/pii/S0042682209008010 | spa |
| dc.identifier.doi | https://doi.org/10.1016/j.virol.2009.12.016 | spa |
| dc.identifier.issn | 0042-6822 / 1096-0341 (Electrónico) | spa |
| dc.identifier.uri | http://hdl.handle.net/10554/45908 | |
| dc.language | spa | spa |
| dc.rights.licence | Atribución-NoComercial 4.0 Internacional | * |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc/4.0/ | * |
| dc.source | Virology; Vol. 399 Núm. 1 (2010) | spa |
| dc.subject.keyword | Rotavirus | spa |
| dc.subject.keyword | Humans | spa |
| dc.subject.keyword | Interferon-gamma | spa |
| dc.subject.keyword | Interleukin 13 | spa |
| dc.subject.keyword | Interleukin-2 | spa |
| dc.subject.keyword | Interleukin-10 | spa |
| dc.subject.keyword | Interleukin-17 | spa |
| dc.subject.keyword | Transforming growth factor beta | spa |
| dc.subject.keyword | T-lymphocytes | spa |
| dc.subject.keyword | Regulatory | spa |
| dc.title | A TGF-B mediated regulatory mechanism modulates the T cell immune response to rotavirus in adults but not in children | spa |
| dc.type | info:eu-repo/semantics/article | |
| dc.type.hasversion | http://purl.org/coar/version/c_ab4af688f83e57aa | |
| dc.type.local | Artículo de revista | spa |