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Assessment of placental extracellular vesicles-associated fas ligand and TNF-related apoptosis-inducing ligand in pregnancies complicated by early and late onset preeclampsia

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dc.contributor.authorAyala Ramírez, Paola
dc.contributor.authorMachuca-Acevedo, Catalina
dc.contributor.authorGámez, Tatiana
dc.contributor.authorQuijano Gómez, Sandra Milena
dc.contributor.authorBarreto Prieto, Alfonso
dc.contributor.authorSilva Herrera, Jaime Luis
dc.contributor.authorOlaya Contreras, Mercedes
dc.contributor.authorGarcía-Robles, Reggie
dc.contributor.authorRivatrem
dc.contributor.corporatenamePontificia Universidad Javeriana. Facultad de Medicina. Instituto de Genética Humana. Grupo de investigación Instituto de Genética Humana
dc.contributor.corporatenamePontificia Universidad Javeriana. Facultad de Medicina. Hospital Universitario San Ignaciospa
dc.contributor.corporatenamePontificia Universidad Javeriana. Facultad de Medicina. Departamento de Patología
dc.contributor.javerianateacherAyala Ramírez, Paola
dc.contributor.javerianateacherQuijano Gómez, Sandra Milena
dc.contributor.javerianateacherSilva Herrera, Jaime Luis
dc.contributor.javerianateacherOlaya-C, Mercedes
dc.contributor.javerianateacherGarcía-Robles, Reggie
dc.coverage.cityBogotá (Colombia)
dc.coverage.spatialColombia
dc.coverage.temporal2018
dc.date.accessioned2022-05-31T17:18:22Z
dc.date.available2022-05-31T17:18:22Z
dc.date.created2021-07-23
dc.description.abstractPreeclampsia (PE) is a hypertensive disorder that affects 2–8% of pregnancies and is one of the main causes of fetal, neonatal, and maternal mortality and morbidity worldwide. Although PE etiology and pathophysiology remain unknown, there is evidence that the hyperactivation of maternal immunity cells against placental cells triggers trophoblast cell apoptosis and death. It has also been reported that placenta-derived extracellular vesicles (EV) carry Fas ligand (FasL) and Tumor necrosis factor-related apoptosisinducing ligand (TRAIL) and trigger apoptosis in Jurkat T cells. This study aimed to quantify and compare FasL and TRAIL expression in EV derived from cultures of placenta explants from women with PE (early versus late) and women with uncomplicated pregnancies. Also, the study assessed EV capacity to induce apoptosis in Jurkat T cells. The authors isolated EV from placenta explant cultures, quantified FasL and TRAIL using ELISA, and analyzed EV apoptosis-inducing capability by flow cytometry. Results showed increased FasL and TRAIL in EV derived from placenta of women with PE, and increased EV apoptosis-inducing capability in Jurkat T cells. These results offer supporting evidence that EV FasL and TRAIL play a role in the pathophysiology of PE.spa
dc.description.comunidadMujeres embarazadas
dc.description.esciNOspa
dc.description.indexingRevista Internacional - Indexadaspa
dc.description.orcidhttps://orcid.org/0000-0002-0141-1149
dc.description.orcidhttps://orcid.org/0000-0003-2482-0954
dc.description.orcidhttps://orcid.org/0000-0001-6822-0374
dc.description.orcidhttps://orcid.org/0000-0002-6804-0979
dc.description.publindexA1
dc.description.quartilescopusQ1spa
dc.description.quartilewosQ1spa
dc.formatPDFspa
dc.format.mimetypeapplication/pdfspa
dc.identifierhttps://www.frontiersin.org/articles/10.3389/fphys.2021.708824/fullspa
dc.identifier.doihttps://doi.org/10.3389/fphys.2021.708824spa
dc.identifier.instnameinstname:Pontificia Universidad Javerianaspa
dc.identifier.issn1664-042Xspa
dc.identifier.reponamereponame:Repositorio Institucional - Pontificia Universidad Javerianaspa
dc.identifier.repourlrepourl:https://repository.javeriana.edu.cospa
dc.identifier.urihttp://hdl.handle.net/10554/60055
dc.relation.citationendpage8spa
dc.relation.citationstartpage1spa
dc.relation.citationvolume12spa
dc.relation.ispartofjournalFrontiers in Physiologyspa
dc.rights.coarhttp://purl.org/coar/access_right/c_abf2spa
dc.rights.licenceAtribución-NoComercial 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/*
dc.subjectPregnancyspa
dc.subjectHypertension Disorder Complicating Pregnancyspa
dc.subjectExosome (Vesicle)spa
dc.subjectApoptosisspa
dc.subjectPlacental Culturespa
dc.titleAssessment of placental extracellular vesicles-associated fas ligand and TNF-related apoptosis-inducing ligand in pregnancies complicated by early and late onset preeclampsia
dc.type.coarhttp://purl.org/coar/resource_type/c_2df8fbb1spa
dc.type.hasversionhttp://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.localArtículo de revistaspa

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