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Specificity and sensitivity of aquaporin 4 antibody detection tests in patients with neuromyelitis optica : a meta-analysis

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dc.contributor.authorRuíz Gaviria, Rafael
dc.contributor.authorBaracaldo, Ivan
dc.contributor.authorCastañeda, Camilo
dc.contributor.authorRuiz Patiño, Alejandro
dc.contributor.authorAcosta Hernández, Andres
dc.contributor.authorRosselli Cock, Diego Andrés
dc.contributor.corporatenamePontificia Universidad Javeriana. Facultad de Medicina. Departamento de Epidemiología Clínica y Bioestadística
dc.contributor.corporatenamePontificia Universidad Javeriana. Facultad de Medicina. Departamento de Medicina Interna. Grupo de Investigación de Enfermedades Crónicas del Adulto
dc.date.accessioned2020-03-25T15:29:45Z
dc.date.accessioned2020-04-15T13:24:44Z
dc.date.available2020-03-25T15:29:45Z
dc.date.available2020-04-15T13:24:44Z
dc.date.created2015-06-10
dc.description.abstractenglishObjective: Antibodies against water channel protein aquaporin 4 (AQP4) in astrocytes play a role in the etiology and physiopathology of neuromyelitis optica (NMO); detection of this immunoglobulin in serum is highly suggestive of this diagnosis. There are several immunoassays to detect the antibody with different sensitivities and specificities. We conducted a meta-analysis to determine the overall diagnostic accuracy from these tests. Methods: We conducted a systematic review in five different electronic databases: Pubmed, Embase, The Cochrane Library, Scopus, Database of Abstracts of Reviews of Effect (DARE) and Lilacs. We included both case control and consecutive enrollment studies that evaluated the performance of the immunoassays in patients with suspected NMO in comparison with the 2006 Wingerchuk diagnostic criteria. Articles were assessed by two different reviewers, who also extracted data. Results: 30 studies for three different immunoassays were included in the meta-analysis. To obtain a summary estimate for the sensitivity and specificity with 95% confidence interval a bivariate random effect model was used. The approximated sensitivity for the cell based assay (CBA), the tissue-based assay (TBA) and the ELISA test were 0.76(95% CI 0.67–0.82), 0.59(95% CI 0.50–0.67), and 0.65(95% CI 0.53– 0.75) respectively. The mean specificity of the CBA was 0.99 (95% CI 0.97–0.99), TBA 0.98 (95% CI 0.97– 0.99) and ELISA 0.97(95% CI 0.96–0.99). Conclusions: AQP4 detection in serum with immunoassay is a great tool for the diagnosis of patients with NMO, due to the high specificity, allowing the clinician to differentiate this disease from other neurological conditions that resemble NMO.spa
dc.description.paginas345-349spa
dc.description.quartilescopusQ1spa
dc.description.quartilewosQ2spa
dc.description.tipoarticuloArtículo originalspa
dc.formatPDFspa
dc.format.mimetypeapplication/pdfspa
dc.format.soportePapel / Electrónicospa
dc.identifierhttps://www-sciencedirect-com.ezproxy.javeriana.edu.co/science/article/pii/S2211034815000747spa
dc.identifier.doihttps://doi.org/10.1016/j.msard.2015.06.003spa
dc.identifier.issn2211-0348 / 2211-0356 (Electrónico)spa
dc.identifier.urihttp://hdl.handle.net/10554/47817
dc.languagespaspa
dc.rights.licenceAtribución-NoComercial 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/*
dc.sourceMultiple Sclerosis and Related Disorders; Vol. 4 Núm. 4 (2015)spa
dc.subject.keywordNeuromyelitis opticaspa
dc.subject.keywordAquaporin 4spa
dc.subject.keywordDiagnostic testspa
dc.subject.keywordImmunoassaysspa
dc.subject.keywordSensitivityspa
dc.subject.keywordSpecificityspa
dc.titleSpecificity and sensitivity of aquaporin 4 antibody detection tests in patients with neuromyelitis optica : a meta-analysisspa
dc.typeinfo:eu-repo/semantics/article
dc.type.hasversionhttp://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.localArtículo de revistaspa

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