Logotipo del repositorio
 

Genotoxicity and hypomethylation of LINE-1 induced by electronic cigarettes

Vista sencilla de ítem
dc.contributor.authorBernal Forigua, Camila
dc.contributor.authorCamero Bautista, Carlos Andres
dc.contributor.authorPinzón García, María José
dc.contributor.authorRodríguez, Sergio
dc.contributor.authorCanas, Alejandra
dc.contributor.authorRojas, Adriana
dc.contributor.corporatenamePontificia Universidad Javeriana. Facultad de Medicina. Departamento de Medicina Interna. Neumologíaspa
dc.contributor.corporatenamePontificia Universidad Javeriana. Facultad de Medicina. Instituto de Genética Humana. Grupo de investigación Instituto de Genética Humana
dc.contributor.javerianateacherCanas, Alejandra
dc.contributor.javerianateacherRojas, Adriana
dc.coverage.cityBogotá (Colombia)spa
dc.coverage.spatialColombiaspa
dc.date.accessioned2023-08-28T16:04:40Z
dc.date.available2023-08-28T16:04:40Z
dc.date.created2023-04-11
dc.description.abstractenglishCurrently, the marketing of electronic cigarettes as a safe alternative to smoking has increased, which is associated with greater use of these devices, especially among young people and smokers interested in quitting tobacco cigarettes. Given the growing use of this type of product, there is a need to determine the consequences of electronic cigarettes on human health, especially since many of the compounds contained in the aerosol and liquid of these devices have a high potential to be carcinogenic and genotoxic. Additionally, many of these compounds' aerosol concentrations exceed the safe limits. We have evaluated the levels of genotoxicity and changes in DNA methylation patterns associated with vaping. We analyzed a total of 90 peripheral blood samples from a population of vapers (n = 32), smokers (n = 18), and controls (n = 32), in which the frequencies of genotoxicity were determined by the cytokinesis-blocking micronuclei (CBMN) assay and the patterns of methylation of the repetitive elements of LINE-1 through the Quantitative Methylation Specific PCR (qMSP) assay. Here we show an increase in genotoxicity levels associated with vaping habits. Additionally, the group of vapers showed changes at the epigenetic level specifically associated with the loss of methylation of the LINE-1 elements. These changes in LINE-1 methylation patterns were reflected in its representative RNA expression detected in vapers.spa
dc.description.comunidadIndividuos vapeadoresspa
dc.description.esciNospa
dc.description.indexingRevista Internacional - Indexadaspa
dc.description.orcidhttps://orcid.org/0000-0003-1555-6661spa
dc.description.orcidhttps://orcid.org/0000-0001-5650-6471spa
dc.description.orcidhttps://orcid.org/0000-0002-1051-6356spa
dc.description.orcidhttps://orcid.org/0000-0003-3975-2835spa
dc.description.orcidhttps://orcid.org/0000-0001-8528-4433spa
dc.description.publindexA1spa
dc.description.quartilescopusQ1spa
dc.description.quartilewosQ1spa
dc.formatPDFspa
dc.format.mimetypeapplication/pdfspa
dc.identifierhttps://www.sciencedirect.com/science/article/pii/S0147651323004049spa
dc.identifier.doihttps://doi.org/10.1016/j.ecoenv.2023.114900spa
dc.identifier.instnameinstname:Pontificia Universidad Javerianaspa
dc.identifier.issn0147-6513 / 1090-2414 (Electrónico)spa
dc.identifier.reponamereponame:Repositorio Institucional - Pontificia Universidad Javerianaspa
dc.identifier.repourlrepourl:https://repository.javeriana.edu.cospa
dc.identifier.urihttp://hdl.handle.net/10554/65324
dc.language.isoengspa
dc.relation.citationendpage9spa
dc.relation.citationstartpage1spa
dc.relation.citationvolume256spa
dc.relation.ispartofjournalEcotoxicology and Environmental Safetyspa
dc.rights.coarhttp://purl.org/coar/access_right/c_abf2spa
dc.rights.licenceAtribución-NoComercial 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/*
dc.subject.keywordElectronic cigarettesspa
dc.subject.keywordVapingspa
dc.subject.keywordMicronucleispa
dc.subject.keywordGenotoxicityspa
dc.subject.keywordDNA methylationspa
dc.subject.keywordLINE-1spa
dc.titleGenotoxicity and hypomethylation of LINE-1 induced by electronic cigarettesspa
dc.type.coarhttp://purl.org/coar/resource_type/c_6501spa
dc.type.hasversionhttp://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.localArtículo de revistaspa

Archivos

Bloque original
Mostrando 1 - 1 de 1
Miniatura
Nombre:
Genotoxicity and hypomethylation of LINE-1 induced by electronic cigarettes.pdf
Tamaño:
3.55 MB
Formato:
Adobe Portable Document Format
Descripción:
Artículo
Descargar
Bloque de licencias
Mostrando 1 - 1 de 1
No hay miniatura disponible
Nombre:
license.txt
Tamaño:
2.54 KB
Formato:
Item-specific license agreed upon to submission
Descripción:
Descargar

Colecciones

Artículos
Artículos