Logotipo del repositorio
 

Increased tissue factor and thrombomodulin expression and histopathological changes in placentas of pregnancies with preeclampsia

Vista sencilla de ítem
dc.contributor.authorAyala Ramírez, Paola Andrea
dc.contributor.authorRodríguez Sarmiento, Jorge Luis
dc.contributor.authorOlaya Contreras, Mercedes
dc.contributor.authorGarcía Robles, Reggie
dc.contributor.authorPoveda Gutiérrez, Alisson Geraldine
dc.contributor.authorPineda Buitrago, Tatiana
dc.contributor.corporatenamePontificia Universidad Javeriana. Facultad de Medicina. Instituto de Genética Humana
dc.contributor.corporatenamePontificia Universidad Javeriana. Facultad de Medicina. Departamento de Patología
dc.date.accessioned2020-03-02T18:31:50Z
dc.date.accessioned2020-04-15T13:34:48Z
dc.date.available2020-03-02T18:31:50Z
dc.date.available2020-04-15T13:34:48Z
dc.date.created2015-10-13
dc.description.abstractenglishINTRODUCTION: Preeclampsia has a global frequency of 2–8% and a frequency of 10% in developing countries. In Colombia, preeclampsia causes 42% of maternal mortality. Alterations in placental homeostasis have been proposed to be involved in its pathophysiology. The aim of this study was to compare mRNA and protein levels of tissue factor (F3) and thrombomodulin (THBD) and the histopathological findings of placentas. MATERIALS AND METHODS: We studied 16 placentas from patients with preeclampsia and 19 term placentas with uncomplicated pregnancy. An expert pathologist, who was masked to the group assignment, conducted an evaluation to determine specific histological changes. Assessments of mRNA and protein levels of F3 and THBD were performed using real-time PCR and ELISA, respectively. RESULTS: Cases and controls differed in the frequency of decidual arteriopathy (p = 0.027), acute infarction (p = 0.001) and hyperplasia of the syncytiotrophoblast (p = 0.0017). Cases had increased levels of F3 mRNA (p = 0.0124) and protein (p < 0.0001) and THBD mRNA (p < 0.0001) and protein (p < 0.0001). CONCLUSION:In placenta of patients with preeclampsia, we detected abnormal expression of F3 and THBD with increased protein and mRNA levels. The role of these molecules in the pathogenesis of this disease and in alterations of hemostatic and histopathological aspects of placentas need further studying.spa
dc.description.paginas31-39spa
dc.description.quartilescopusQ3spa
dc.description.tipoarticuloArtículo originalspa
dc.formatPDFspa
dc.format.mimetypeapplication/pdfspa
dc.format.soportePapel / Electrónicospa
dc.identifierhttps://login.ezproxy.javeriana.edu.co/login?url=https://search-ebscohost-com.ezproxy.javeriana.edu.co/login.aspx?direct=true&db=edselc&AN=edselc.2-52.0-84962628739&lang=es&site=eds-livespa
dc.identifier.doihttps://doi.org/10.3233/NPM-16915034spa
dc.identifier.issn1934-5798 / 1934-5798 (Electrónico)spa
dc.identifier.urihttp://hdl.handle.net/10554/47420
dc.languagespaspa
dc.rights.licenceAtribución-NoComercial 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/*
dc.sourceJournal of Neonatal - Perinatal Medicine; Vol. 9 Núm. 1 (2015)spa
dc.subject.keywordHypertension of pregnancyspa
dc.subject.keywordTHBDspa
dc.subject.keywordHistopathologyspa
dc.subject.keywordMRNAspa
dc.titleIncreased tissue factor and thrombomodulin expression and histopathological changes in placentas of pregnancies with preeclampsiaspa
dc.title.englishIncreased tissue factor and thrombomodulin expression and histopathological changes in placentas of pregnancies with preeclampsia.spa
dc.typeinfo:eu-repo/semantics/article
dc.type.hasversionhttp://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.localArtículo de revistaspa

Archivos

Bloque original
Mostrando 1 - 1 de 1
No hay miniatura disponible
Nombre:
Journal of Neonatal (2016).pdf
Tamaño:
331.36 KB
Formato:
Adobe Portable Document Format
Descripción:
Artículo
Descargar
Bloque de licencias
Mostrando 1 - 1 de 1
No hay miniatura disponible
Nombre:
license.txt
Tamaño:
2.54 KB
Formato:
Plain Text
Descripción:
Descargar

Colecciones

Artículos
Artículos