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The natural history of solitary post-nephrectomy kidney in a pediatric population

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dc.contributor.ascribedclinicalteacherEspitaleta, Zilac
dc.contributor.authorSánchez Basto, Catalina
dc.contributor.authorPuerto Niño, Angie Katherine
dc.contributor.authorFernandez, Nicolas
dc.contributor.authorCastillo Arteaga, Mariangel
dc.contributor.authorEspitaleta, Zilac
dc.contributor.authorQuintero Gómez, Ana María
dc.contributor.authorPerez Niño, Jaime
dc.contributor.corporatenamePontificia Universidad Javeriana. Facultad de Medicina. Departamento de Cirugía y Especialidades. Urologíaspa
dc.contributor.corporatenamePontificia Universidad Javeriana. Facultad de Medicina. Hospital Universitario San Ignaciospa
dc.contributor.corporatenamePontificia Universidad Javeriana. Facultad de Medicina. Departamento de Medicina Interna. Nefrología
dc.contributor.javerianateacherCastillo Arteaga, Mariangel
dc.contributor.javerianateacherFernandez, Nicolas
dc.contributor.javerianateacherPérez Niño, Jaime
dc.coverage.cityBogotá (Colombia)
dc.coverage.spatialColombia
dc.coverage.temporal2005-2015
dc.date.accessioned2022-05-31T17:11:29Z
dc.date.available2022-05-31T17:11:29Z
dc.date.created2019-08-10
dc.description.abstractIntroduction: Children with a solitary post-nephrectomy kidney (SNK) are at potential risk of developing kidney disease later in life. In response to the global decline in the number of nephrons, adaptive mechanisms lead to renal injury. The aim of this study was to determine the prevalence and time of onset of high blood pressure (HBP), proteinuria, glomerular filtration rate (GFR) disruption and renal tubular acidosis (RTA) in children with SNK. Materials and methods: After obtaining the approval from our institution's ethics committee, we reviewed the medical records of patients under 18 years of age who underwent unilateral nephrectomy between January 2005 and December 2015 in three university hospitals. Results: We identified 43 patients, 35 (81.4%) cases of unilateral nephrectomy (UNP) were due to a non-oncologic pathology and Wilm's tumor was identified in 8 (18.6%) cases. In patients with non-oncologic disease, 9.3% developed de novo hypertension, with an average time of onset of 7.1 years, 25% developed proteinuria de novo, with an average time of onset of 2.2 years. For GFR, 21.8% presented deterioration of the GFR in an average time of 3.4 years. Ten (43.5%) patients developed some type of de novo renal injury after UNP. Patients with oncologic disease developed the conditions slowly and none of them developed proteinuria. Conclusions: Taking into account the high rate of long term postoperative renal injury, it can be considered that nephrectomy does not prevent this disease. The follow-up of children with SNK requires a multidisciplinary approach and long-term surveillance to detect renal injury.spa
dc.description.comunidadPacientes pediátricos sometidos a Nefrectomía unilateral
dc.description.esciNospa
dc.description.indexingRevista Internacional - Indexadaspa
dc.description.orcidhttps://orcid.org/0000-0002-1017-9791
dc.description.orcidhttps://orcid.org/0000-0001-8550-5718
dc.description.orcidhttps://orcid.org/0000-0002-9675-5963
dc.description.orcidhttps://orcid.org/0000-0001-9350-0722
dc.description.orcidhttps://orcid.org/0000-0003-4710-386X
dc.description.orcidhttps://orcid.org/0000-0002-2231-4321
dc.description.publindexBspa
dc.description.quartilescopusQ3spa
dc.description.quartilewosQ4spa
dc.formatPDFspa
dc.format.mimetypeapplication/pdfspa
dc.identifierhttps://search.scielo.org/?q=spa
dc.identifierhttps://www.scielo.br/j/ibju/a/Mb9xpzTGpc3ZWnbCLc5xX9C/?lang=enspa
dc.identifier.doihttps://doi.org/10.1590/S1677-5538.IBJU.2018.0291spa
dc.identifier.instnameinstname:Pontificia Universidad Javerianaspa
dc.identifier.issn1677-5538 / 1677-6119 (Electrónico)spa
dc.identifier.reponamereponame:Repositorio Institucional - Pontificia Universidad Javerianaspa
dc.identifier.repourlrepourl:https://repository.javeriana.edu.cospa
dc.identifier.urihttp://hdl.handle.net/10554/60041
dc.language.isoengspa
dc.relation.citationendpage1237spa
dc.relation.citationissue6spa
dc.relation.citationstartpage1227spa
dc.relation.citationvolume45spa
dc.relation.ispartofjournalInternational Braz J Urol: official journal of the Brazilian Society of Urologyspa
dc.rights.coarhttp://purl.org/coar/access_right/c_abf2spa
dc.rights.licenceAtribución-NoComercial 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/*
dc.subjectSolitary Kidneyspa
dc.subjectRenal Insufficiencyspa
dc.subjectNephrectomyspa
dc.titleThe natural history of solitary post-nephrectomy kidney in a pediatric population
dc.type.coarhttp://purl.org/coar/resource_type/c_6501spa
dc.type.hasversionhttp://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.localArtículo de revistaspa

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