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Role of RUNX2 transcription factor in epithelial mesenchymal transition in non-small cell lung cancer lung cancer: epigenetic control of the RUNX2 P1 promoter

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dc.contributor.authorHerreño Pachon, Angelica Maria
dc.contributor.authorRamirez Rodriguez, Andrea
dc.contributor.authorChaparro Ramírez, Viviana Paola
dc.contributor.authorFernández Sánchez, Maria José
dc.contributor.authorCanas, Alejandra
dc.contributor.authorMorantes Ariza, Carlos Fabian
dc.contributor.authorMoreno Niño, Olga María
dc.contributor.authorBruges Maya, Ricardo
dc.contributor.authorMejía Nuñez, Juan Andrés
dc.contributor.authorBustos Fernández, Fernando José
dc.contributor.authorMontecino Leonard, Martín Alejandro
dc.contributor.authorRojas, Adriana
dc.contributor.corporatenamePontificia Universidad Javeriana. Facultad de Medicina. Instituto de Genética Humana. Grupo de investigación Instituto de Genética Humana
dc.contributor.corporatenamePontificia Universidad Javeriana. Facultad de Medicina. Departamento de Medicina Interna. Neumología
dc.contributor.corporatenamePontificia Universidad Javeriana. Facultad de Medicina. Departamento de Ciencias Fisiológicas
dc.contributor.javerianateacherFernández Sánchez, Maria José
dc.contributor.javerianateacherCanas, Alejandra
dc.contributor.javerianateacherMoreno Niño, Olga María
dc.contributor.javerianateacherRojas, Adriana
dc.coverage.cityBogotá (Colombia)spa
dc.coverage.spatialColombiaspa
dc.coverage.temporal2017
dc.date.accessioned2020-02-26T21:25:17Z
dc.date.accessioned2020-04-15T13:33:33Z
dc.date.available2020-02-26T21:25:17Z
dc.date.available2020-04-15T13:33:33Z
dc.date.created2019-05-20
dc.description.abstractenglishLung cancer has a high mortality rate in men and women worldwide. Approximately 15% of diagnosed patients with this type of cancer do not exceed the 5-year survival rate. Unfortunately, diagnosis is established in advanced stages, where other tissues or organs can be affected. In recent years, lineage-specific transcription factors have been associated with a variety of cancers. One such transcription factor possibly regulating cancer is RUNX2, the master gene of early and late osteogenesis. In thyroid and prostate cancer, it has been reported that RUNX2 regulates expression of genes important in tumor cell migration and invasion. In this study, we report on RUNX2/p57 overexpression in 16 patients with primary non-small cell lung cancer and/or metastatic lung cancer associated with H3K27Ac at P1 gene promoter region. In some patients, H3K4Me3 enrichment was also detected, in addition to WDR5, MLL2, MLL4, and UTX enzyme recruitment, members of the COMPASS-LIKE complex. Moreover, transforming growth factor-b induced RUNX2/p57 overexpression and specific RUNX2 knockdown supported a role for RUNX2 in epithelial mesenchymal transition, which was demonstrated through loss of function assays in adenocarcinoma A549 lung cancer cell line. Furthermore, RUNX2 increased expression of epithelial mesenchymal transition genes VIMENTIN, TWIST1, and SNAIL1, which reflected increased migratory capacity in lung adenocarcinoma cells.spa
dc.description.comunidadPacientes con Cáncer de pulmón
dc.description.indexingRevista Internacional - Indexada
dc.description.orcidhttps://orcid.org/0000-0002-5962-4817
dc.description.orcidhttps://orcid.org/0000-0002-4785-6848
dc.description.orcidhttps://orcid.org/0000-0001-6461-2725
dc.description.orcidhttps://orcid.org/0000-0003-3975-2835
dc.description.orcidhttps://orcid.org/0000-0002-0826-6191
dc.description.orcidhttps://orcid.org/0000-0002-3649-9515
dc.description.orcidhttps://orcid.org/0000-0001-8528-4433
dc.description.paginas1 - 13spa
dc.description.publindexA1
dc.description.quartilescopusQ2spa
dc.description.tipoarticuloArtículo originalspa
dc.formatPDFspa
dc.format.mimetypeapplication/pdfspa
dc.format.soportePapel / Electrónicospa
dc.identifierhttps://journals.sagepub.com/doi/full/10.1177/1010428319851014?rfr_dat=cr_pub++0pubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.orgspa
dc.identifier.doihttps://doi.org/10.1177/1010428319851014spa
dc.identifier.issn1010-4283 / 1423-0380 (Electrónico)spa
dc.identifier.urihttp://hdl.handle.net/10554/47387
dc.languageengspa
dc.rights.licenceAtribución-NoComercial 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/*
dc.sourceTumor Biology; Volumen 41 Número 5 (2019)spa
dc.subject.keywordRUNX2spa
dc.subject.keywordEpithelial mesenchymal transitionspa
dc.subject.keywordLung cancerspa
dc.subject.keywordEpigeneticspa
dc.subject.keywordHistonespa
dc.titleRole of RUNX2 transcription factor in epithelial mesenchymal transition in non-small cell lung cancer lung cancer: epigenetic control of the RUNX2 P1 promoterspa
dc.typeinfo:eu-repo/semantics/article
dc.type.hasversionhttp://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.localArtículo de revistaspa

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