Logotipo del repositorio
 

Epigenetic control of the EWS-FLI1 promoter in Ewing's sarcoma

Vista sencilla de ítem
dc.contributor.authorMontoya, C.
dc.contributor.authorRey, L.
dc.contributor.authorRodríguez Sarmiento, Jorge Luis
dc.contributor.authorFernández Sánchez, Maria José
dc.contributor.authorTroncoso, D.
dc.contributor.authorCanas, Alejandra
dc.contributor.authorMoreno Niño, Olga María
dc.contributor.authorHenríquez, B.
dc.contributor.authorRojas, Adriana
dc.contributor.corporatenamePontificia Universidad Javeriana. Facultad de Medicina. Departamento de Patología
dc.contributor.corporatenamePontificia Universidad Javeriana. Facultad de Medicina. Departamento de Medicina Interna. Neumología
dc.contributor.corporatenamePontificia Universidad Javeriana. Facultad de Medicina. Instituto de Genética Humana. Grupo de investigación Instituto de Genética Humana
dc.contributor.corporatenamePontificia Universidad Javeriana. Facultad de Medicina. Departamento de Ciencias Fisiológicas
dc.contributor.javerianateacherRodríguez Sarmiento, Jorge Luis
dc.contributor.javerianateacherFernández Sánchez, Maria José
dc.contributor.javerianateacherCanas, Alejandra
dc.contributor.javerianateacherMoreno Niño, Olga María
dc.contributor.javerianateacherRojas, Adriana
dc.coverage.cityBogotá (Colombia)spa
dc.coverage.spatialColombiaspa
dc.date.accessioned2021-03-19T15:34:24Z
dc.date.available2021-03-19T15:34:24Z
dc.date.created2020-02-05
dc.description.abstractenglishEwing sarcoma (ES) is a primary bone marrow tumor that very rarely develops in extra-osseous tissues, such as lung. The hallmark of ES tumors is a translocation between chromosomes 11 and 22, resulting in a fusion protein, commonly referred to as EWS-FLI1. The epigenetic profile (histone acetylation and methylation enrichment of the promoter region) that may regulate the expression of the aberrant transcription factor EWS-FLI1, remains poorly studied and understood. Knowledge of epigenetic patterns associated with covalent histone modification and expression of enzymes associated with this process, can contribute to the understanding of the molecular basis of the disease, as well as to the identification of possible molecular targets involved in expression of the EWS-FLI1 gene, so that therapeutic strategies may be improved in the future. In the present study, the transcriptional activation and repression of the EWS-FLI1 fusion gene in ES was accompanied by selective deposition of histone markers on its promoter. The EWS-FLI1 fusion gene was evaluated in two patients with ES using conventional cytogenetic, fluorescence in situ hybridization and nested PCR assays, which revealed that the aberrant expression of the EWS-FLI1 gene is accompanied by enrichment of H3K4Me3, H3K9ac and H3K27ac at the promoter region.spa
dc.description.comunidadPacientes con Sarcoma de Ewing
dc.description.indexingRevista Internacional - Indexadaspa
dc.description.orcidhttps://orcid.org/0000-0002-0084-0339
dc.description.orcidhttps://orcid.org/0000-0001-6461-2725
dc.description.orcidhttps://orcid.org/0000-0003-3975-2835
dc.description.orcidhttps://orcid.org/0000-0002-0826-6191
dc.description.orcidhttps://orcid.org/0000-0001-8528-4433
dc.description.publindexA1
dc.description.quartilescopusQ2spa
dc.description.quartilewosQ3spa
dc.formatPDFspa
dc.format.mimetypeapplication/pdfspa
dc.identifierhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7057940/spa
dc.identifier.doihttps://doi.org/10.3892/or.2020.7489spa
dc.identifier.instnameinstname:Pontificia Universidad Javerianaspa
dc.identifier.issn1021-335X / 1791-2431 (Electrónico)spa
dc.identifier.reponamereponame:Repositorio Institucional - Pontificia Universidad Javerianaspa
dc.identifier.repourlrepourl:https://repository.javeriana.edu.cospa
dc.identifier.urihttp://hdl.handle.net/10554/53284
dc.language.isoengspa
dc.relation.citationendpage1207spa
dc.relation.citationissue4spa
dc.relation.citationstartpage1199spa
dc.relation.citationvolume43spa
dc.relation.ispartofjournalOncology Reportsspa
dc.rights.coarhttp://purl.org/coar/access_right/c_abf2spa
dc.rights.licenceAtribución-NoComercial 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/*
dc.subject.keywordEwing's sarcomaspa
dc.subject.keywordEpigeneticsspa
dc.subject.keywordHistonespa
dc.subject.keywordFISHspa
dc.subject.keywordTranslocationspa
dc.titleEpigenetic control of the EWS-FLI1 promoter in Ewing's sarcomaspa
dc.type.coarhttp://purl.org/coar/resource_type/c_6501spa
dc.type.hasversionhttp://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.localArtículo de revistaspa

Archivos

Bloque original
Mostrando 1 - 1 de 1
Miniatura
Nombre:
Artículo.pdf
Tamaño:
564.59 KB
Formato:
Adobe Portable Document Format
Descripción:
Descargar
Bloque de licencias
Mostrando 1 - 1 de 1
No hay miniatura disponible
Nombre:
license.txt
Tamaño:
2.54 KB
Formato:
Item-specific license agreed upon to submission
Descripción:
Descargar

Colecciones

Artículos
Artículos
Artículos
Artículos